SPR servicess
There are companies and universities that provide SPR services such as drug discovery, epitope mapping and kinetics.
Let me know about the companies which should be listed here by contacting the sprpages.
Are you a vendor or a university facility and do you want to be listed on the sprpages, please use the following document.
Reaction Biology is a trusted research partner for your biophysical needs. Equipped with 4 Biacore 8K(+) instruments (SPR), we offer kinetics and affinity determination, antibody characterization, binding specificity profiling, high-throughput compound screening, custom assay development, and more. Reaction Biology provides project-tailored solutions to assure the highest chance of success in biomolecular interaction research using SPR services by using a broad biophysics knowledge base and excellent instrument coverage. Pair your SPR work with in-house custom protein production to streamline your assay, or explore our other biophysical offerings: ITC, TSA, and MST.
Creative Biolabs offers comprehensive label-free interaction measurement and antibody characterization services, leveraging advanced Biacore 1K and 8K systems to deliver precise and reliable results. With extensive experience and a team of seasoned experts, we provide end-to-end support, including method development, validation, sample analysis, and data transfer in any required format, ensuring the data is ready for publication or regulatory filing.
Our SPR-based label-free interaction studies cover a wide range of applications, such as protein-protein and protein-DNA interactions, kinetic parameter analysis, mechanism of action studies, and competition assays. Additionally, we specialize in antibody characterization, offering services like affinity measurements, specificity studies, cross-reactivity analysis, and epitope mapping. For comparability studies of biosimilars, we evaluate binding to recombinant targets and Fc receptors, along with optional analysis services such as hybridoma sequencing, epitope binning, and calorimetry. Creative Biolabs is dedicated to providing tailored solutions to meet diverse research needs.
To contact Creative Biolabs use this link.
Genovac Antibody Discovery, a leading contract research organization headquartered in Fargo, ND, with an additional site in Freiburg, Germany, offers fully integrated antibody discovery and development services. By leveraging genetic immunization and a variety of antigen formats, we elicit robust immune responses across multiple host species. Specializing in challenging targets, Genovac supports clients through every stage of the process, from antibody discovery to production and detailed characterization.
Our advanced capabilities in BLI and high-throughput SPR enable precise kinetic analyses and comprehensive epitope binning, delivering high-quality binding data to define antibody interactions. These strengths provide a distinct advantage in addressing complex project requirements and advancing therapeutic and diagnostic innovations.
Please reach out to learn how our team can support your project.
Kimialysis not a CRO: we are your partner of choice for the most challenging SPR analyses, bringing a level of expertise and support that stands out in the field. We offer advanced SPR/SPRi biomolecular interaction analysis services for biotech and pharmaceutical companies engaged in early-stage (biologics selection, lead characterization...) and late-stage (assessment of biosimilarity, quality control & batch testing...) development. Leveraging our patented K-One® surface chemistry, our capabilities in chip functionalization and kinetic measurements are limitless.
K-One® is Kimialys’ technology platform and the culmination of over 10 years of academic research led at Paris-Saclay University, standing as the most effective surface chemistry for biosensing applications to date. Our technology allows precise control of the surface interactions, ensuring more than 90% of functional ligands, while protecting the surface from non-specific interactions. We can immobilize any ligands, ranging from large to small molecules, and even cells; our approach is remarkably robust, ensuring ligands are not denatured and remain active through repeated analysis cycles, underlining the reproducibility of the assays conducted with our chips. The protection of the chip surface brought by K-One® offers the unique ability to work with complex matrix (plasma, supernatants...), minimizing drastically background noise, while still achieving the highest sensitivity. Lastly, our K-One® coated chips are compatible with any standard system (such as streptavidin, protein A/G, Ni-NTA...), enabling to handle any biotinylated molecule or His-tagged protein seamlessly.
If you have complex SPR/SPRi analyses, Kimialys is your best partner to succeed where everyone fails! To discuss one of your projects, you can contact us via mail.
BindKin Bio is a CRO located in Davis, CA, 95618 - United States specializing in label-free and real-time binding kinetics with native proteins for drug discovery aims.
We offer:
- High-throughput screening for small molecule and protein “binders” (thousands of compounds) using BLI.
- Direct binding kinetics analysis to measure the affinity (KD), association rates (ka), and dissociation rates (kd) between target proteins and a variety of biomolecular drugs, including small molecules, antibodies, peptides, etc. using SPR.
The instrumentation consist of a BLI-Octet 384 RED and the SPR-LSPR instrument from Nicoya with robotic injection system (OpenTrons OT-2 robotic liquid handler).
The Core Facility Biomolecular interactions and Crystallography of the Central European Institute of Technology in Brno in the Czech Republic is a great place to have your interactions analysed. From analytical centrifugation, Calorimetric titration and sample quality assessment. These techniques complement the SPR and BLI available on the spot. Please look at the services and make contact.
Creative Peptides is specialized in the process development and manufacturing of bioactive peptides. We are dedicated to offering custom peptide synthesis, process development, manufacturing as well as catalog products for customers in the industry and research areas. Creative Peptides offers SPRi (Surface Plasmon Resonance imaging) services including Biochip design and printing, Bio-interactions analysis (binding affinity and kinetic processes detection), Summary and analysis of the results.
Rapid Novor develops cutting-edge proteomics services, including SPR, protein sequencing, HDX-MS epitope mapping, and antibody discovery via polyclonal antibody sequencing. Label-free evaluation of antibody-antigen binding relies on a Surface Plasmon Resonance technology from Nicoya called OpenSPR. This nanotechnology-based SPR platform enables immobilization of binding partners in both orientations with low levels for bulk shift even in the most complex buffers. Look at our internet page for more information.
Gifford Bioscience specialise in Receptor Pharmacology. We use SPR techniques and radioligand assays to determine kinetic and affinity parameters for receptor-ligand and protein-protein interactions. We adhere tightly to our core specialism, to ensure that our PhD scientists have a deep knowledge of our assays. As a result, we have a loyal customer base: in 2021, 86% of our business was repeat business, coming from the same scientist we have worked with before. We are always happy to discuss potential requirements and assay design. Contact us for a chat.
Profacgen has organized a team of scientists with extensive experience in the study of PPIs to offer you one-stop service on your PPI project. We can help with your experiment design, carry out your experiments, and perform data analysis. We have established in our lab a series of assays to help with your research, including high throughput interaction screening assays such as Yeast two-hybrid screening and phage display technology, interaction strength and kinetics assays such as Surface Plasmon Resonance (SPR). Each approach has its own advantages and weaknesses in terms of sensitivity and specificity.
Type of techniques used: SPR, ITC, BLI
Creative Biostructure has in the past years, accumulated rich experience in SPR technology and many experimental data, such as bio-macromolecular interactions, antibody screening/characterization, as well as consistency evaluation of protein/antibody. Our team of scientists with a shared scientific background in virology and biophysical technologies provides custom assay development services for coronavirus infection research and supports SPR experimental design and data analysis. We aim to help customers gain faster access to high-quality binding kinetics data so that you can better understand disease pathways, accelerate lead generation and candidate validation.
Type of techniques used: SPR, ITC, BLI, FRET, STD, MST
Beactica is a service provider specialized in molecular interaction analysis by SPR for exploratory drug discovery. Since 2006, Beactica has supported small biotechs and big pharmas globally in assay development, screens for novel hit matter, and characterization of drug leads. All our staff are distinguished scientists with extensive experience from many types of drug target classes. Some client projects have later been published in e.g. PNAS and Nature, and are summarized at our website.
Beactica strive for scientific excellence, quick project turnarounds, and a customer centered service experience. Get in contact for a free quote.
| Company | Services | Techniques |
|---|---|---|
| Biaffin | Kinetics, Thermodynamics, Concentration | SPR |
| Profacgen | Kinetics, Epitope mapping, Quantification | SPR, BLI, ITC |
| Gifford | Kinetics | SPR |
| Creative peptides | Kinetics, epitope mapping, ligand fishing | SPRi |
| Creative biolabs | Kinetics | SPR |
| Total Scientific | Kinetics, Thermodynamics | SPR |
| Jubilant Biosys | Kinetics, Fragment screening, Competition assay | SPR |
| Episentum | Kinetics, SPR method development | SPR |