Introduction

Surface Plasmon Resonance (SPR) is a powerful technique to measure biomolecular interactions in real-time in a label free environment. While one of the interactants is immobilized to the sensor surface, the other are free in solution and passed over the surface. Association and dissociation is measured in arbitrary units and displayed in a graph called the sensorgram.

The Biomolecular Interaction Analysis is not limited to proteins. Interactions between DNA - DNA, DNA - protein, lipid - protein and hybrid systems of biomolecules and non-biological surfaces can be investigated.
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BiaMethodWriter

[BiaMethodWriter] BiaMethodWriter is a program to write the Biacore 2000 and 3000 automation methods in a more interactive way. The program uses pop up menus and dialog boxes to fill in the different parts. Remembering these odd parameters is not necessary any more.

The program calculates vial and buffer volumes and estimates the total runtime. The report function creates an overview of the method and a vial layout with required volumes. The program uses colored text formatting which gives a better overview of the method and makes it easier to find errors.
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ASDlib

[ASDL Logo] This site has been reviewed by The Analytical Sciences Digital Library.


Scrubber

[Biologic Version 2 of Scrubber extends the program with kinetic models for simple binding (association and dissociation rates) and a model for mass transport limited binding.
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Your help

Your help is appreciated! I need feedback to keep up the good work. Maybe you have nice tips for every body or you can contribute in a more substantial way to the SPR-pages.

Did you use the BiamethodWriter? I am looking for your comments.


Web links

Did you find the web links with many books, suppliers, machines, software and other links?

Did you look at the FAQ and download pages? You will find a lot of interesting stuff there.