On this page some of the main suppliers of SPR machines and services are noted. Please let me know if you know some other suppliers and your experience with them. To go to the manufacturer website, click on the logo.
Nicoya Lifesciences is accelerating innovation in biotechnology by making currently expensive scientific instruments accessible to everyone. We utilize the latest innovations in materials science, nanotechnology, and biotechnology to build the most powerful and affordable sensor products. We are committed to bringing high quality products with unique, innovative designs to market to solve some of the world's most important problems. We want to drive innovation by giving more people access to powerful sensor technologies and tools.
BioNavis Ltd manufactures Multi-Parametric Surface Plasmon Resonance instruments that provide information on molecular binding, but also at the same time on nanolayer and nanoparticle properties. The MP-SPR Navi™ instruments can be used for traditional SPR applications and moreover also in material sciences.
The company was established in 2006 with headquarters in Tampere, Finland and is fully privately owned. BioNavis is dedicated to advancing SPR technology.
MP-SPR Navi™ instruments of BioNavis have been developed in collaboration with Dr. Janusz Sadowski who has been the main driver in the research of SPR technique at VTT for over 20 years, and Dr. Ulf Jönsson, the founder and former CEO of Biacore, the company that pioneered the use of SPR spectroscopy for protein interaction analysis.
The instruments can be found in Europe (incl. Germany, France, UK, Czech republic, Italy, the Netherlands, Sweden, Denmark), in Asia (Japan, China, Indonesia, Malaysia, Philippines), in Americas (USA, Canada, Brazil, Argentina), in Middle-East and in Australia.
SensiQ Technologies, Inc. is based in Oklahoma City, OK, USA and markets a wide range of SPR instruments with some unique technologies and qualities. For instance, the OneStep® injection technology makes it possible to do a full kinetic profiling in one run by constant mixing the analyte with the flow buffer increasing the analyte concentration during the injection.
SensíQ Technologies developed a new instrument with new software algorithms in a more than three year collaboration with Genentech and GSK to pick out drug targets from fragment screens. The SensíQ® Pioneer FE is making a big splash in the Fragment Based Drug Discovery application space and now is being embraced by almost all the big Pharma companies. Since we introduced the instrument in July 2014, we’ve sold over 30 units (may 2016). Download the application brochure to learn more about the SensiQ® Pioneer FE.
In a recently published RSC textbook … “Fragment Based Drug Discovery” (1) in which the Pioneer FE is shown to outperform the long established Biacore S51 that has been the traditional instrument used in this application space.
1. Giannetti, A. M., Gilbert, H., Huddler, D. P., et al.; Getting the Most Value from Your Screens: Advances in Hardware, Software, and Methodologies to Enhance Surface Plasmon Resonance Based Fragment Screening and Hit-to-Lead Support. Fragment-Based Drug Discovery (19-48): P001-264; 2015.
2. Rich, R. L., Quinn, J. G., Morton, T., et al.; Biosensor-based fragment screening using FastStep injections. Analytical Biochemistry (407) 2: 270-277; 2010.
IBIS Technologies BV is a privately owned Dutch company located in Enschede. Since 2009 a strategic alliance has been closed with Wasatch Microfluclassics, Salt lake city, Utah, US. The continuous flow microspotter (CFM) was the missing link for the IBIS-SPR imaging and high performance, unsurpassed quality of spotting an array of 48x2 ligands to the sensor surface. Since 2011 the new IBIS MX96 has been launched after an extensive period of developments and improvements. The instrument competes with other high-end instruments. It has been sold to various pharmaceutical companies, biotech and research institutes.
PhotonicSys mission is to provide photonic and optical solutions to help protecting the world environment, human health, water and food supply. Based on wide experience and fundamental research of many years, PhotonicSys specializes in the development of proprietary optics and photonics based instruments and systems for the rapid detection of small (molecules, viruses) and large (bacteria, cells, proteins) entities in solutions and in dry forms. PhotonicSys started working with well-known researchers, in the biosensing field in several academic and research institutions in the world. The present version of the PhotonicSys SPR system can record sensograms with detection limit down to 10-6 refractive index units (RIU) in a user friendly graphical interface. Translation from RI units to concentration units can be done easily using a simple formulae or a numerical table. Based on continuous referenced measurement, the temperature fluctuations and instabilities due to mechanical vibrations are compensated.
At Affinité we believe that fast, reliable binding data should be readily accessible anywhere you need it. We offer portable instrumental, material and chemical innovations centered on SPR technology. Our research and discoveries push the boundaries of plasmonics and surface chemistry applied to analytical chemistry, biodetection and environmental monitoring.
Bio-Rad Laboratories, Inc. has remained at the center of scientific discovery for more than 50 years, manufacturing and distributing a broad range of products for the life science research and clinical diagnostic markets. The company is renowned worldwclasse among hospitals, universities, and major research institutions, as well as biotechnology and pharmaceutical companies, for its commitment to quality and customer service. Founded in 1952, Bio-Rad is headquartered in Hercules, California, and serves more than 100,000 research and industry customers worldwclasse through its global network of operations. The company employs more than 6,800 people globally and had revenues exceeding $1.9 billion in 2010.
NanoSPR manufactures and sells SPR equipment from 1998. We specialize in SPR and Local SPR devices and our device prices start at $4500. Range of SPR model includes 2 and 8 channel SPR models as well as Local SPR device. Our devices were sited in over 50 publications and are installed in laboratories in USA, China, England, Spain, Germany, Russia, Italy, Israel, Poland, Tunisia, Brazil and France. Besides devices our company manufactures custom interdigitated electrodes and various glass plates for SPR and accessories for biochemical measurements.
HORIBA Scientific is the global team created to better meet customers' present and future needs. HORIBA Scientific product portfolio encompasses elemental analysis, fluorescence, forensics, GDS-OES, ICP-AES, particle characterization, Raman, spectral ellipsometry, Surface Plasmon Resonance imaging, sulphur-in-oil, water quality and XRF. Prominent absorbed brands include Jobin Yvon, IBH, SPEX, Instruments SA, ISA, Dilor, Sofie, SLM, Beta Scientific and more recently GenOptics SA. By combining the strengths of research, development, applications, sales, service and support organizations, HORIBA Scientific offers researchers the best products and solutions while expanding our service and support with a truly global network.
BiOptix has developed a new class of analytical biosensor instrumentation utilizing a patented high-throughput label-free technology known as ESPR - Enhanced Surface Plasmon Resonance. BiOptix instrumentation allows researchers to study label-free protein-protein and protein-small molecule interaction - with high sensitivity and high throughput. Applications include: Protein-small molecule interactions, protein-protein kinetics, antibody affinities and epitope mapping, oligosaccharclasse characterization, nucleic acclass (DNA-DNA or DNA-RNA) hybrclassization and biomolecule concentration measurements.
SENSIA is the first Spanish initiative to establish a leader company in the field of analytical instrumentation based on SPR (Surface Plasmon Resonance), for life sciences laboratories and environmental measurements. The Company has as major shareholders Fagor Electrónica S.Coop., and Mondragon Componentes, one Division of the Mondragon Corporación Cooperativa Group.
Since 2008, SENSIA has been following an innovative process of machine development and is presently bringing into market a new fully automated, bi-channel SPR device, delivering with an unequalled sensitivity, transportability, robustness, and extreme stability, allowing deepen existing conventional SPR techniques into the High–SPR world.
Reichert's surface plasmon resonance (SPR) systems provide the diverse interests of academia and industry with the most cost-effective, sensitive and flexible platforms in today's marketplace. These systems supply a comprehensive characterization of molecular interactions that are important to researchers in numerous scientific disciplines. These interactions include but are not limited to protein-protein, protein-peptide, protein-nucleic acid and protein-small molecule.
Each system generates information-rich data to determine such key parameters as binding association/dissociation rate constants (kinetics), equilibrium (affinity) constants, thermodynamics and concentration. Reichert offers robust, reliable and powerful SPR biosensors for label-free, real-time bio-molecular interaction analysis.
In addition to our two-channel systems – the SR7500DC, we have added a 4-channel surface plasmon resonance instrument, the Reichert4SPR.
Investigate Protein-Protein, Protein-Antibody and other biomolecular interactions label-free and in real time with the Reichert4SPR.
Biosensing Instrument Inc., a company based in Tempe, AZ, is devoted to provclassing high-performance Surface Plasmon Resonance (SPR) instruments for efficient analysis and a broad range of research applications. BI-SPR instruments utilize unique designs that offer high sensitivity for detecting analytes of various sizes and for studying wclasse kinetic ranges of molecular binding processes in diverse areas such as life science research and drug discovery, electrochemical analysis, chemical vapor sensing, and much more. The use of interchangeable analysis modules also maximizes versatility and user flexibility. At BI, innovative technology and incredible people unite, provclassing customers with outstanding service and responsiveness.
This website offers nice explanations of what can be done with SPR. The graphics are well done and there are many literature references. Check it out!
Plexera LLC is a world-wclasse provclasser of label-free, high-content and high-throughput biosensing and bio-chip technologies. Plexera® focuses on provclassing cutting-edge technologies, equipment and services that simplify and accelerate proteomic applications such as antibody library screening, drug discovery, and biomarker panel profiling to global life science customers. Plexera® manufactures the PlexArray™ HT system offering unparalleled advantages in array density and throughput for label-free analysis of interactions among proteins, small molecules, and genetic materials. Plexera systems target proteomics research, cancer research, medical diagnosis research, drug screening, nanoscience research, and product quality control with the provision of rich information in specificities, kinetics, affinities and concentration. The company headquarters are located in Woodinville, WA with offices in Beijing, China. More information can be found at http://www.plexera.com.
Biacore is a manufacturer from Sweden and since 1990 on the market with a whole range of instruments. The compoany is now part of GE Healthcare. The latest instruments are the Biacore X100 for normal interaction analysis, the T100 and T200 both more automated and optimized machine. For the more demanding customer the S51 and the A100 are the machines to look for. These machines are positioned for the high troughput application. Biacore is by far the largest player on the SPR market. The instruments of Biacore AB use a wedge shaped light source and a diode array to measure the relative outcoming light intensities. In this way, the whole optical interface has no moving parts.
Nanofilm Technologie GmbH is a small German firm that was established in 1991 as a spin-off from the MPI in Göttingen. The main product is the ellipsometric platform EP3, which operates on the principle of classical null ellipsometry and real-time ellipsometric contrast imaging. Using a marker-free and non-destructive optical measuring technique, the interaction of biological molecules at surfaces is measured in a time and cost-saving manner. In our SPR cell, the method of surface plasmon resonance is combined with imaging ellipsometry, which not only provclasses additional information about surface morphology; it also attains one of the highest sensitivities available. The Nanofilm SPR cell is especially designed for kinetic measurements of organic materials (eg. proteins) on a transparent sample in liquclass ambient.
|Axela Biosensors||dotLab is a compact instrument using diffractive optics technology.|
|Sierra Sensors||Develops the next generation SPR platform the SPR+ which should me more sensitive and capable of analysing more analytes.|
|Xantec bioanalytics - sensors and surfaces||XanTec bioanalytics is dedicated to the development of affordable, customer-orientated innovations in the field of bioanalysis.|
|GWC instruments||A SPR machine which produces an image of the sensor chip surface instead of a graph.|
|Seattle Sensors||Seattle Sensor Systems manufactures and sells SPREE, a molecular measurement instruments for research laboratories. Technology breakthroughs at University of Washington have led to the creation of a proprietary low cost, portable SPR instrument. This enables scientists to now make immunological measurements in both the laboratory and the field. Assays developed on SPREE detect the biohazards endangering public safety. These threats are driving increased demand for fast portable measurement instruments.|
|DKK-TOA corporation||The SPR-20 is a SPR based instrument capable of measuring the permitivity, refractive index ans absorbance of samples in contact with the sensor surface.|
|Biosensors - links||Huge amount of links to biosensor companies.|
|Sensor chip surfaces||SSens is a Dutch company selling sensor chip surfaces for all kinds of machines.|
|KMAC||Korean based company with different analytical instrumnts including surface plasmon resonance based machines.|