Episentec – The Label-Enhanced SPR Company

Label-enhanced SPR greatly improves the sensitivity and specificity of SPR, and can be used directly on standard SPR instruments without any hardware modification.
Label-enhanced SPR is based on labelling of one interactant with specialized dye labels combined with software-based curve shape analysis of the entire SPR dip curve. In this way, an extremely sensitive and fully specific measure of the binding of dye-labelled compound is obtained and plotted as an enhanced sensorgram or ‘epigram’.

The benefits include:

  • Label-free interaction analysis with label-enhanced readout
  • 100x improved detectability of small molecules due to enhanced sensitivity
  • 100x improved detectability of proteins and antibodies due to enhanced specificity

Episentec logo
Conventional SPR
Conventional SPR
Enhanced SPR
Enhanced SPR

It is important to emphasize that the technology can be used on standard SPR instruments (e.g. Biacore), and that label-free affinity and kinetics data can be obtained by selecting an appropriate assay format (e.g. competition or inhibition).

For more info, please check out the website of episentec or contact episentec at This email address is being protected from spambots. You need JavaScript enabled to view it..