Digital SPR Article

Digital SPR


Nicoya, a leading provider of advanced analytical instruments for the biotechnology and pharmaceutical industries, today announced the launch of Alto, the world’s first fully-automated, high-throughput benchtop surface plasmon resonance (SPR) system. As the first-ever SPR instrument to integrate digital microfluidics (DMF), artificial intelligence (AI), and nanotechnology, Alto provides high quality, label-free interaction analysis. This breakthrough product reduces the time and cost of drug discovery, enabling scientists to better understand and cure human diseases faster.

Unlike other SPR instruments in the market today, Alto uses DMF technology. DMF is a liquid-handling technology capable of accurately controlling and manipulating discrete nanoliter droplets with electricity. It removes the need for any physical pumps, valves, or tubes; instead replacing them with a low-cost disposable cartridge that is compatible with the standard well-plate form factor. This enables highly accurate and repeatable measurements of kinetics and affinity, without labels and with extremely small sample volumes.

“We’ve spent years working with the world’s leading scientists and researchers to better understand the issues they experience with SPR, including high costs, low throughput, frequent downtime, and complex assay design requirements,” said Ryan Denomme, co-founder and CEO of Nicoya. “Alto is the third instrument we have released to date, but the first to use DMF technology for SPR, which solves all of these issues.”

Fluidic cartridge

Groundbreaking new SPR system uses digital microfluidics technology and flexible 16-channel design to reduce the time and cost of drug discovery. With Alto’s, digital approach to SPR, all fluidics are contained within the disposable cartridge, so scientists never have to run another cleaning cycle again. It also allows for precise handling of 2μL sample volumes for full kinetics, which is 500X less than the sample volume of traditional SPR instruments. Alto also ensures crude sample compatibility and requires no maintenance.

Every aspect of Alto is designed to make it user friendly and accessible, from the flexible 16-channel design and automated serial dilutions to the seamless integration with robotics. With a state-of-the-art software solution featuring impressive AI-driven automation capabilities and flexibility, Alto provides sample-in/answer-out data, industry leading throughput, and 24/7 runtime.

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Visit the Alto site at Nicoya

Nicoya Alto instrument
Alto instrument

Nicoya Alto cartridge
Alto cartridge

Contact Nicoya

Nicoya crewNicoya is a leading provider of advanced analytical instruments for the biotechnology and pharmaceutical industries. The Canadian company’s mission is to improve human life by helping scientists succeed. Its instruments are used by hundreds of world-renowned researchers in over 40 different countries.
More information about Nicoya can be found at nicoyalife.com.