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LSPR instruments utilize a broad band white light source such as an LED to illuminate the nanoparticle sensor substrate. A spectrometer serves as the detector and can be placed in either a transmission or reflection arrangement. The spectrometer provides a reading of the absorbance spectrum of the sensor substrate. The nanoparticle substrates have a characteristic absorbance peak in the visible spectrum due to the LSPR effect. The properties of this absorbance peak (spectral position, absorbance height) are dependent on the local optical properties surrounding the nanoparticles. When a molecule binds to the surface of the nanoparticle, it changes the local optical properties and causes the absorbance peak to change. The properties of the absorbance peak can be monitoring in real-time, providing time resolved molecular analysis on the nanoscale. The size, shape, and material of the nanoparticles can be tuned in order to maximize sensor performance for specific applications.

LSPR principle
LSPR principle

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Nicoya LifesciencesOpenSPR by Nicoya Lifesciences utilizes localized surface plasmon resonance (LSPR) for label-free analysis. LSPR is similar to SPR, but it uses nanoparticles of gold rather than a continuous gold film to produce an optical resonance. LSPR’s main advantages are simplicity of the optical design, highly tunable optical properties, no need for temperature control, and robustness. Nicoya has developed a proprietary manufacturing process to create nanoparticle sensors that are highly uniform and stable. Sensors can be functionalized using standard immobilization and coupling chemistry.

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Nicoya OpenSPR-XT